Benefits of Vitamin D: A Nursing Home Perspective
Vitamin D supplementation can increase bone density. In one study, people with vitamin D deficiency were supplemented with 50,000 D international units of vitamin D twice a week, increasing the bone density of the lumbar spine and femoral neck for five weeks.
Vitamin D and calcium can reduce fractures in the elderly, but vitamin D alone cannot effectively reduce the risk of falls or fractures. People over 65 with low vitamin D content have an increased risk of hip fractures and decreased muscle mass and strength.
Vitamin D can reduce the risk of falls. It can do this by improving muscle function. A low vitamin D level in the blood is related to the worst muscle function, and a higher vitamin D level is related to better muscle function. When supplemented with vitamin D, people with a low baseline serum concentration of 25-hydroxyvitamin D (between 10-20 ng/ml) may benefit the most in terms of muscle strength.
When you consume 700 to 1,000 international units of vitamin D supplements daily, the risk of falling is reduced, when 500,000 units of cholecalciferol are given once a year, the chance of falling increases.
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Vitamin D and cancer has been established. Vitamin D can help prevent colon cancer, breast cancer, and prostate cancer. Precancerous lesions of the gut and breast are related to the lack of vitamin D receptors in animals.
Many cancers are related to low vitamin D status. People with inadequate vitamin D status have an increased risk of colorectal cancer. An analysis showed that those who consume 1000 international units of vitamin D per day have a reduced risk of colorectal cancer. Another study showed that vitamin D intake was negatively related to colorectal cancer risk. Although the data on vitamin D is positive, the research is inconsistent. The National Cancer Institute does not recommend or oppose the use of vitamin D supplements to reduce the risk of colorectal cancer or any other cancer.
Some studies have shown that serum 25-hydroxyvitamin D concentration is linked to reducing breast cancer risk, but found no statistical significance. More research is needed to determine the role of vitamin D in breast cancer risk.
There is some evidence that vitamin D can be harmful. A large-scale prospective study showed that vitamin D does not lower the risk of prostate cancer, but that higher circulating vitamin D levels are linked to an increased risk of aggressive disease. Other research suggests that people with the highest vitamin D levels may have a higher risk of pancreatic cancer.
While some studies have shown that vitamin D can reduce the risk of certain cancers, the current evidence does not recommend the use of high doses of vitamin D to prevent cancer. A large-scale analysis of more than 16,000 people showed that overall cancer mortality has nothing to do with vitamin D status at baseline. Overall, research does not support vitamin D’s role in cancer prevention. More research is needed to determine the exact link between cancer and vitamin D.
Vitamin D affects the immune system. Vitamin D can reduce the risk of autoimmune diseases in animals. Conditions that can be affected by vitamin D status include type 1 diabetes, multiple sclerosis, and inflammatory bowel disease.
Vitamin D supplementation in early infants can reduce the risk of type 1 diabetes. One study showed that people with a serum concentration of 25-hydroxyvitamin D less than 20 ng / mL would have an approximately two-fold increase in the incidence of multiple sclerosis in the future. Currently, the only animal, in vitro, and epidemiological studies suggest an association between diabetes / multiple sclerosis and vitamin D. A randomized controlled trial is needed to reach a definitive conclusion.
A higher vitamin D is associated with a lower risk of Crohn’s disease. The reduced regulation of vitamin D is linked to the development of autoimmune processes in animals (including inflammatory bowel disease). Taking vitamin D can improve these symptoms.
Vitamin D can help to fight bacterial and viral infections. Vitamin D levels are related to tuberculosis. Vitamin D deficiency common in patients with tuberculosis. Vitamin D may play a role in treating tuberculosis, but more research is needed before this connection is established.
Vitamin D levels may have a beneficial effect on viral respiratory infections, but this relationship has not been firmly established. Several studies have not found an association between vitamin D status and the prevention of viral respiratory infections. A recent analysis showed that vitamin D supplementation could reduce the risk of viral upper respiratory infections and tuberculosis.
Vitamin D and the heart
Vitamin D regulates many genes in the cardiovascular system. Vitamin D deficiency has been linked to heart attack, stroke, high blood pressure, diabetes, peripheral vascular disease, and heart failure. The research on vitamin D and cardiovascular disease. Observational studies have shown a link between cardiovascular disease and vitamin D status. More research is needed to determine the role of vitamin D supplementation in cardiovascular disease.
The renin-angiotensin system is regulated to some extent by vitamin D. Hypertension has an inverse relationship to the serum concentration of 25-hydroxyvitamin D. More research is needed to confirm the causal relationship between vitamin D levels and blood pressure.
In a retrospective study, five of the seven studies showed that serum 25-hydroxyvitamin D levels were negatively correlated with cardiovascular disease. The prevalence of coronary heart disease in people with a low serum 25-hydroxyvitamin D concentration is higher than that in people with a low serum 25-hydroxyvitamin D concentration. Vitamin D supplementation has no beneficial effects on cardiovascular disease risk factors, and there is no benefit after increasing the serum concentration of 25-hydroxyvitamin D from 23 ng/ml to more than 40 ng/ml.
Vitamin D and other diseases
Diabetes is related to vitamin D. The relationship between vitamin D and type 1 diabetes has been discussed above. Low vitamin D levels are associated with type 2 diabetes. A higher intake of vitamin D is associated with a lower risk of type 2 diabetes. Despite these correlations, interventional studies of vitamin D have not proven that vitamin D supplementation increases the risk of developing diabetes. Diabetes.
Vitamin D is essential for brain development so that it may be related to psychopathology. Patients with Alzheimer’s disease and depression have low serum levels of 25-hydroxyvitamin D. These studies have not proven that low vitamin D levels are the cause of these diseases.
Low vitamin D levels can increase the risk of death. While there is a link between vitamin D and all-cause death, it is unclear whether this increased risk of death is related to vitamin D deficiency or merely poor general health. Some studies have shown that cancer patients have higher vitamin D levels and a lower risk of death, but other studies have shown no link between cancer death and serum 25-hydroxyvitamin D levels.